Our Services

Where Science meets Strategy

Strategic Consulting for Nonclinical Drug Development

Expert Guidance tailored to fit your needs and to Drive Your Success

At Akkeri, we specialize in providing scientific strategy and operational support to biotech and pharmaceutical companies navigating the complexities of nonclinical drug development. Whether you need full program support or a specific task, our services are adaptable to help you meet your goals efficiently and effectively.
We bring decades of experience and expertise in nonclinical drug development for all modalities, including extensive knowledge of regulatory pathways. Whether you’re advancing a novel therapy or optimizing an existing program, our team is here to support you at every stage.

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What We Do

Provide strategic and scientific advice by expert consultants

Develop nonclinical program plans to support clinical/CMC/regulatory strategy

Integrate innovative approaches (e.g. NAMs, weight of evidence) to reduce animal usage while maintaining a high level of safety assessment 

Design, implementation, and oversight of nonclinical studies (pharmacology, ADME, toxicology)

Review/write nonclinical study reports to ensure accuracy, quality, and scientific rigor

Provide strategic and scientific advice by expert consultants

Develop nonclinical program plans to support clinical/CMC/regulatory strategy

Design, implementation, and oversight of nonclinical studies (pharmacology, ADME, toxicology)

Study monitoring and CRO qualification

Review/write nonclinical study reports to ensure accuracy, quality, and scientific rigor

Provide integrated interpretation of data and risk analysis/mitigation

Authoring regulatory documents to include: IND/CTA, NDA/BLA/MAA, Investigator Brochure (IB)

Document preparation and meeting participation in support of global Regulatory Authority interactions

Author position papers, targeted data summaries, product labeling

Due diligence and gap analysis

Study monitoring and CRO qualification 

Develop approaches to establish clinical starting dose and dose escalation based on toxicology and pharmacology data

Document preparation for regulatory submissions and meeting participation in support of global Regulatory Authority interactions

Author position papers, targeted data summaries, product labeling

Due diligence and gap analysis - participation in both in- or out-licensing partner discussions

Connect with Our Experts

Our Areas of Expertise

Toxicology Consulting

Nonclinical toxicology is a cornerstone of drug safety evaluation. Our experts design, oversee, and interpret toxicology studies to assess the safety profile of your therapeutic candidates. We help you:
  • Develop study protocols aligned with regulatory requirements.
  • Manage studies and interpret toxicology data for regulatory submissions.
  • Identify and mitigate potential safety concerns early in the development process.
  • Deliver data driven recommendations and justifications for alternative program options

Pharmacology Support

Understanding the pharmacological effects of your drug is critical to its success. Our pharmacology consulting services provide insights into your therapy’s mechanism of action, efficacy, and potential clinical impact. We specialize in:
  • Preclinical pharmacodynamic and pharmacokinetic study design.
  • Translational research to bridge preclinical data with clinical applications.
  • Supporting regulatory submissions with robust pharmacology data and submission quality reports.
  • Confirmatory evidence to support approvals

DMPK Support

The pharmacokinetic and metabolic profile of a drug is the link for putting safety and efficacy into perspective. Our DMPK support can design the appropriate studies and interpret potential nonclinical and clinical impact. We can provide:
  • Nonclinical requirements at various clinical stages
  • Justification for species selection and metabolite liabilities
  • Exposure assessment for safety margin calculations and clinical dose modeling 
  • Drug:Drug Interaction (DDI) liabilities

Regulatory Strategy and Compliance

Navigating regulatory requirements can be a daunting task. Our consultants, including former FDA reviewers, provide the expertise you need to ensure compliance and mitigate risk. We support:
  • IND, NDA, and BLA submission strategies.
  • Compliance with GLP and other regulatory standards.
  • Interactions with global regulatory agencies, including pre-submission meetings.

Cell & Gene Therapy Guidance

Cell and Gene therapies require a unique and specialized approach. Our team is experienced in navigating the scientific and regulatory challenges associated with these innovative treatments. We assist clients with:
  • Designing preclinical studies tailored to cell and gene therapies.
  • Addressing vector-specific safety and efficacy considerations.
  • Developing comprehensive data packages for regulatory meetings and review.

Services We Provide

Scientific Strategy

Experience with various therapeutic modalities
  • Small molecules
  • Biologics
  • Cell and Gene Therapy
  • Vaccines
  • Oligonucleotides

Experience in most therapeutic areas and all stages of development

Experience with common and specialized routes of administration

  • Including: oral, IV, SC, dermal, ocular, inhalation, and direct CNS administration
Pharmacology, ADME, Toxicology study expertise - with individual specialization in
  • Animal models of disease
  • Genetox / Carcinogenicity
  • DART (Developmental and Reproductive Toxicology) and Juvenile Toxicology
  • Safety Pharmacology (CV, Respiratory, CNS)
  • Abuse Liability

Product Quality Assessments
  • Impurities, leachables, excipients

In silico ICH M7 genetic toxicology assessments
  • Leadscope
  • N-nitrosamine CPCA

Regulatory Services

Regulatory advice on nonclinical strategy

Representation for Regulatory Authority interactions for nonclinical topics

Expertise to ensure adequacy of study reports for submission:

  • GLP and ICH compliance
  • SEND implementation
Regulatory authoring
  • All nonclinical components required to support regulatory submissions
  • All writing done by technical experts
  • All documents 100% QC’d

Project management available for additional program support, to include tracking of study report and submission document timelines

Scientific Services

Independent nonclinical program management and operational support

Study design and CRO selection

  • Long standing interactions with most global CROs
  • Current knowledge of individual CRO capabilities

Placement and management of contracted studies

CRO qualification site visits

Global nonclinical study monitoring
  • GLP compliance
  • Scientific integrity
  • Technical performance
  • Monitoring reports provided

Review and ensure quality of final reports

Literature searches and data compilation

Tailored Solutions 

At Akkeri, we understand that no two drug development programs are alike. That’s why we take the time to learn about your specific therapeutic goals and challenges, creating customized strategies that align with your unique needs. From study design to regulatory submission, we provide actionable insights and solutions that drive your program forward.

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